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KMID : 0358619940280020197
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Korean Journal of Physiology
1994 Volume.28 No. 2 p.197 ~ p.202
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A Central Pressor Response to Endogenous Nitric Oxide Synthesis Inhibition in Anesthetized Rats
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Moon Sung-Ho
Yang Min-Joon
Oh Seung-Ho
Kim Mi-Won
Yoo Kwang-Jay
Lee Jong-Eun
Jun Jae-Yeoul
Yeum Cheol-Ho
Yoon Pyung-Jin
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Abstract
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The present study was aimed to determine if endogenous L-arginine-nitric oxide (NO) pathway has central, rather than peripheral, mechanisms in blood pressure regulation. Arterial blood pressure and heart rate responses to acute inhibition of the t-arginine-NO pathway were examined in rats anesthetized with thiopental (50 mg/kg, IP). An intracerebroventricular (ICV) cannula was placed in the left lateral ventricle. The right femoral artery was cannulated to measure arterial blood pressure and the vein to serve as an infusion route. methyl ester (L-NAME) was infused either intracerebroventricularly or intravenously. ICV infusion of L-NAME per minute for 60 min) increased the mean arterial pressure and heart rate. Plasma renin concentrations(PRC) were significantly lower in L-NAME-infused group than in the control. L-Arginine prevented the pressor response to ICV L-NAME. The pressor response was not affected by simultaneous intravenous infusion of saralasin, but was abolished by hexamethonium treatment. Intravenous infusion also increased blood pressure, while it decreased heart rate. These results indicate that endogenous L-arginine-NO pathway has separate central and peripheral mechanisms in regulating the cardiovascular function. The central effect may not be mediated via activation of renin-angiotensin system, but via, at least in part, activation of the sympathetic outflow.
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KEYWORD
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L-Arginine-nitric oxide pathway, Plasam renin concentration, Sympathetic activation
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